Drew caught a line drive by Manny Ramirez to end the third inning, and then limped off the field. Darnell McDonald pinch-hit for him in the bottom of the inning.
"The right hammy is pretty sore," said manager Terry Francona. "When he first came out initially, we were real [worried]. He said he felt like he thought he felt a pop. He has pretty good range of motion. He's sore. We'll get him looked at tomorrow. We'll get him MRI'd in the morning at some point. It's the weekend, but we'll get him looked at. Certainly the hope is that it would be a couple of days. You don't know, you have a lot better look or feel tomorrow when a guy shows up."
Drew did take advantage of the one at-bat he had, hitting a solo homer that just cleared the Monster in the bottom of the first. It was his first at-bat against the Dodgers since opting out of Los Angeles following the 2006 season and signing a five-year deal with the Red Sox.
Drew's homer cleared the Green Monster by inches before hitting the shelf in front of the first row of seats and bouncing back into play. It was initially ruled a double by third-base umpire Paul Nauert.
At the urging of Francona, the umpiring crew reviewed it on the replay monitor in the third-base dugout and ruled it a home run.
It was No. 8 on the season for Drew.
It was the seventh time replay has been used at Fenway since Major League Baseball first implemented the rule late in the 2008 season.
Drew played two years for the Dodgers, and had one of the best seasons of his career in 2006, hitting .283 with 20 homers and 100 RBIs.
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.