Pedroia met with foot specialist Dr. George Theodore on Friday in Boston and got the news he needed.
"He got the go-ahead from the medical people. The doctors looked at him," manager Terry Francona said. "He's going to play second base [Saturday], play [designated hitter] Sunday, take Monday off because we have an off-day and hopefully join us on Tuesday."
The PawSox play the Buffalo Bisons on Saturday at 6:05 p.m. ET and Sunday at 1:05 p.m. at McCoy Stadium.
Pedroia originally went on the disabled list June 26 with a non-displaced fracture of the navicular bone in his left foot in a 5-4 loss to the Giants the day before. Now it appears that he'll finally be able to rejoin the Red Sox.
"Needless to say he was very excited," Francona said. "I got a text from him that said, 'I'm back.'"
Pedroia, who hasn't suffered any setbacks this week while running, is hitting .370 with 12 home runs and 41 RBIs in 295 at-bats this season for the Red Sox.
Chris Cox is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.