Releasing seven weeks of pent up energy (and frustration) while waiting for his broken left foot to mend, Pedroia went 1-for-3 with a walk and a run scored in what is expected to be the first of two rehab games with the PawSox.
"It felt good," Pedroia said. "It's been a while since I played. Later in the game I was a little tired, but overall I felt fine. It's the most I've done since I got hurt, so I'm pretty excited about it."
Prior to the game, Pedroia said he hoped to put the ball in the play in order to give his foot a good workout on the basepaths.
He accomplished that during his first two at-bats. The first resulted in a groundout. Although the play at first base wasn't close, Pedroia was happy with the way he got out of the batter's box.
"My first swing," he said, "it was a curveball down and in. I reacted to it, and I got out of the box just fine. I don't feel like I'm holding anything back."
Pedroia singled in his next trip up, beating out a comebacker that proved too hot for Buffalo starter Michael Antonini to handle.
He worked his way to third, then scored easily on Yamaico Navarro's sacrifice fly to deep left.
In the field, Pedroia handled four chances -- two ground balls and two pop ups -- without incident.
The first of those was a routine grounder by Jesus Feliciano in the top of the third. Pedroia didn't have to move a step, however, as the ball was hit right at him.
"I felt like I was fine," he said. "I got into the rhythm of the game."
Pedroia flied out to right in the bottom of the fifth, then had what might have been his best plate appearance in the seventh -- a gritty, eight-pitch at-bat.
Pedroia took Bison reliever Adam Pettyjohn to a 2-2 count, then battled him for a walk. He remained at first when Carlos Delgado fanned to end the inning.
"That last a-bat was good for me," he said. "I saw a lot of pitches. Then I laid off a 3-2 changeup. I feel like I'm getting ready."
Pedroia will finish his brief stint Sunday, when he'll be the designated hitter.
"Everything's on schedule," he said. "I'll DH tomorrow, and have a day off. Then I'll play on Tuesday."
Dan Hickling is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.