They lost left-hander Cesar Cabral, to the Tampa Bay Rays with pick No. 14, and righty Daniel Turpen, selected by the Yankees at No. 19.
Cabral was signed by the Red Sox as an international free agent in 2005. Turpen was the player Boston acquired in its July 31 trade with the Giants involving Ramon Ramirez.
The Red Sox are reasonably confident that both players will be returned to them by the end of Spring Training. If Rule 5 Draft picks don't make their new team's Opening Day roster, they are offered back to their original team for $25,000.
"We lost, at least for the time being, two players in the Rule 5 [Draft], and we wish them well with the new organizations," Red Sox general manager Theo Epstein said. "But, hopefully, they soon will be with their old organizations, and we'll get them back. We'll see."