Unlike in Arizona, the DH is in effect, which means manager Terry Francona can trot out his "A" team. There will be no need to sit someone from the trio of Mike Lowell, Kevin Youkilis and David Ortiz.
Ortiz, meanwhile, can toss aside his first baseman's mitt until June 18, when the Sox open a three-game set at Atlanta.
After a 3-4 road trip, the Red Sox will try to get back on a roll at Fenway, where they are 19-10 this season. Veteran knuckleballer Tim Wakefield takes the ball for the Sox. Aaron Cook counters for Colorado.
Todd Helton, who was rumored to be Boston-bound during the winter, will make his second career trip to Fenway.Pitching matchup
BOS: RHP Tim Wakefield (5-7, 4.22 ERA)
Wakefield was able to corral his knuckleball enough to strike out a season-high eight hitters and walked just two against the Oakland A's on Wednesday night. The three runs he allowed was his fewest in a start since May 10. He still took the loss though. COL: RHP Aaron Cook (4-2, 4.54 ERA)
Cook has typically pitched six innings, while giving up three or four runs, in the majority of his 13 starts this season. But he's been winning -- he's 4-1 in his past seven starts. He allowed five runs on seven hits in six innings against Houston in his last outing, but the Rockies came back to win. Three starts ago, Cook hurled a five-hit complete game in a win over the Giants. Player to watch
J.D. Drew is 4-for-8 lifetime against Cook with a double, a triple, homer and five RBIs. Tickets
Buy tickets now to catch the game in person. On the Internet
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WRKO 680, WROL (Español) Up next
Wednesday: Red Sox (Curt Schilling, 6-2, 3.49) vs. Rockies (Josh Fogg, 1-5, 5.06), 7:05 p.m. ET
Thursday: Red Sox (Josh Beckett, 9-0, 2.88) vs. Rockies (Jeff Francis, 5-5, 3.81), 7:05 p.m. ET
Friday: Red Sox (Julian Tavarez, 3-4, 5.25) vs. Giants (Barry Zito, 6-6, 4.02), 7:05 p.m. ET
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.