Gabbard is taking the rotation slot vacated by the ailing Curt Schilling. The last time the Sox saw Gabbard was May 20, when he pitched them to a 6-3 victory over the Braves at Fenway.
The left-hander is in the midst of a solid season for Triple-A Pawtucket, where he is 7-2 with a 3.14 ERA in 14 starts.
Gabbard will be opposed by Felix Hernandez, who fired a one-hit gem against Boston on April 11 at Fenway.
With two games left on this nine-game road trip, the Red Sox are 4-3. Meanwhile, Boston will try to snap a six-game skid at Safeco Field that dates back to July of last season.
BOS: LHP Kason Gabbard (1-0, 3.60 ERA)
The left-hander will be recalled from Triple-A Pawtucket to make the start in place of Curt Schilling, who was placed on the 15-day disabled list with shoulder tendinitis. Gabbard was called up for a start on May 20 against the Braves and he earned the win, giving up six hits and two runs over five innings. Safeco Field was where Gabbard made his Major League debut on July 22, 2006. In that one, Gabbard took the loss, but pitched well, giving up two earned runs over 5 1/3 innings.
SEA: RHP Felix Hernandez (4-4, 4.00 ERA)
Hernandez got back on the right track in his last outing, shutting out the Pirates in eight innings of work while striking out nine. The last time he faced the Red Sox he recorded the ninth one-hitter in Mariners history on April 11 at Boston, the first nine-inning one-hitter for Seattle since Randy Johnson did it on July 16, 1998.
Player to watch
Look for Alex Cora to get the start at shortstop in place of Julio Lugo, who is hitless in his last 29 at-bats. The Red Sox are 20-6 when Cora starts.
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Wednesday: Red Sox (Daisuke Matsuzaka, 9-5, 4.01) at Mariners (Ryan Feierabend, 1-2, 8.20), 4:35 p.m. ET
Friday: Red Sox (Tim Wakefield, 7-8, 4.52) vs. Rangers (Robinson Tejeda, 5-7, 6.57), 7:05 p.m. ET