Making the start at shortstop, Lowrie played seven innings and went 2-for-3 with two RBIs. His performance included a double.
Lowrie is expected to again play for Pawtucket on Friday, and he could be cleared to be activated by the Red Sox as early as Saturday, when the Sox take on the Yankees.
The switch-hitter, who overtook Marco Scutaro for Boston's starting shortstop position in mid-April, was sidelined with a bruised left shoulder. He has been on the disabled list since June 17.
Lowrie has played four times for Pawtucket this week.