The switch-hitting shortstop, recovering from a left shoulder strain, will complete his Minor League rehab with Triple-A Pawtucket this weekend, serving as the designated hitter on Friday night and then playing shortstop in Saturday's game.
Assuming that goes well, Lowrie will have a down day on Sunday and fly with the Red Sox that night for their six-game road trip against the Twins and Mariners.
There was originally some thought that Lowrie could return to Boston's lineup as early as Saturday, when the Red Sox will face Yankees ace lefty CC Sabathia. But upon further review, the club decided to make a more conservative schedule.
"I think we just felt like we might have been pushing it a little bit," said Red Sox manager Terry Francona.
Lowrie got two hits, including a double, in his game on Thursday at Pawtucket. He also looked good in the field.
"Real good," Francona said. "He swung the bat very well and made a diving play right on that shoulder. He did fine. If you start pushing it a little bit, not a lot comes of that."