Lowrie had started the game at shortstop, despite the right-handed Colby Lewis on the mound, and went for 1-for-2 with an RBI single before his departure. He was replaced in the bottom of the fourth by Mike Aviles, who roped an RBI single during Boston's eight-run outburst and finished the day 2-for-3.
"Jed's just stiff," said Francona. "I think probably from a little bit of fatigue. He's played a lot. He just grabbed me on the way up. I don't think we'll play him tomorrow, but he'll certainly be available, so we're OK there. That might be me overreacting a little bit. [I] just don't want to lose guys."
Lowrie missed nearly two months earlier this year with a left shoulder strain. The 27-year-old has yet to accumulate more than 300 at-bats in a season with the Red Sox.
Jason Mastrodonato is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.