The move back to the DL on Saturday comes just four days after Pedroia was activated. Pedroia served as the designated hitter on Tuesday at Tropicana Field and was out of the lineup on Wednesday and again on Friday following an off-day for the Red Sox.
"I mean, I was told that was a possibility how it could respond," Pedroia said. "You've just got to try to find a way to get through it and stay positive and just let some things kind of calm down and heal a little bit. Once that happens, get back out there and go."
Red-hot Eduardo Nunez, who was acquired from the Giants on July 26 to move around the infield for Boston, will continue to hold down second base while Pedroia is out. The Red Sox recalled southpaw Robby Scott from Triple-A Pawtucket to take Pedroia's roster spot.
Pedroia's DL stint is retroactive to Wednesday. The earliest he is eligible to play again is Aug. 19 at Fenway Park against the Yankees.
There is no timetable for Pedroia's return to action. It will all depend on how he responds.
"I don't think right now that there's a date or a number of days that says he's going to be back in the lineup," said Red Sox manager John Farrell. "Pedey will be back when he's first available, and hopefully that's as quick as possible. But we have to stay focused on what his needs are and what's the best thing for him."
"Once it calms down, I'll be out there as fast as I can," said Pedroia.
Is another surgery a possibility in the offseason?
"I don't know," said Pedroia. "I mean, I hope not. That's why we're trying to find ways to get around it and get me out there playing."
Though losing Pedroia again as the pennant race is heating up is tough timing, the Red Sox remain optimistic that their longest-tenured player can contribute down the stretch and hopefully deep into the postseason.
"There's nothing that we have right now that suggests he won't be back to us. There's been no talk of any kind of another procedure or anything similar to what he went through last offseason," said Farrell.
In 86 games this season, Pedroia is slashing .303/.378/.406 with six homers and 54 RBIs.
"One of the leaders of our team both in the clubhouse and in between the lines. You have that type of player, an All-Star caliber player, in the middle of the diamond, those are difficult to replace," said Farrell. "And that's not to take anything away from Eduardo and the work that he's put in, but Pedey, we're talking about a Gold Glove second baseman, a guy that was on pace to have one of his better RBI-type seasons. So, yeah, we miss him. And we're looking forward to the day that he returns."
Ian Browne has covered the Red Sox for MLB.com since 2002. Follow him on Twitter @IanMBrowne and Facebook. This story was not subject to the approval of Major League Baseball or its clubs.