But the infield prospect, who was called up on such short notice that he got in the Red Sox's dugout five minutes before Thursday night's game, is looking forward to soaking up every aspect of his first bit of service time in the Major Leagues.
"The first time being called up, there's excitement and the thought of how much work has gone into it and how much I've put into doing this and how long I've dreamed about it," said Lowrie. "It's just a good opportunity for me to come up here and get some experience."
Lowrie, a shortstop by trade, can also play second base and third. With Lowell out of the mix, the latter position is where he figures to see the bulk of his action during his stay with the Red Sox.
"I get more comfortable every day there," said Lowrie. "It's a position I never really played, even growing up. I always played shortstop. It's something I get more comfortable with day in and day out. It's growing on me. I do enjoy it."
For the most part, the lineup without Lowell will have Kevin Youkilis at third base and Sean Casey at first.
But manager Terry Francona won't just forget about Lowrie and relegate him to the bench.
"If he's here for two weeks, one thing we don't want him to do is sit every day," Francona said. "That's no good. That kind of gets in the way of his development. It seems like it will be a minimum of two weeks, because Mikey is on the DL. We'll probably work him in a couple of times a week over there, at the minimum. I told him to just kind of soak up everything he can and learn everything he can and ask questions and try to help us win games."
The switch-hitting Lowrie got to Fenway just in time to witness his first Red Sox-Yankees series.
"I can't wait," said Lowrie. "It's going to be something I'll be able to say the rest of my life, my first [full] series is the Yankees. There's not much I can say about it. Just go out there and play and have a good time with it."
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.