That's about to change. It's just a matter of whether Lowrie plays his natural position of shortstop or starts at third.
"He'll play," said Francona. "Where, I'm not sure. He'll play third or short, we'll see. Probably third. Wouldn't mind giving 'Case' a day off. I've already told [Lowrie] to get ready to play somewhere."
The switch-hitting Lowrie is eager to get started. At the same time, he doesn't want to get overly excited and become overwhelmed by the moment.
"I'll go into the day and get my work in and approach it like any other day," Lowrie said.
Lowrie's parents have already made arrangements to fly from Oregon to New York for the series the Red Sox are playing against the Yankees on Wednesday and Thursday.
His relatives might only be able to watch his Major League debut on television.
"I don't think anybody is going to be able to make it out for this trip," Lowrie said.
After a dramatic comeback victory Monday, the Sox will try to extend their season-long winning streak to four games.
BOS: RHP Tim Wakefield (1-0, 3.27 ERA)
Wakefield battled through his last start against the Tigers, despite not having his usual command. In fact, the knuckleballer wound up pitching well enough to win, giving up three hits and one earned run over five innings while throwing 108 pitches. He walked five and struck out five. Wakefield is 9-8 with a 4.50 ERA in 23 career appearances against the Indians.
CLE: RHP Paul Byrd (0-2, 11.05 ERA)
Byrd has really struggled in the early going. His pitches have not been sharp, and the results speak for themselves. In two starts against the A's and Angels, Byrd has given up 11 runs (nine earned) on 13 hits with four walks in just 7 1/3 innings. He lasted only three innings against the Angels on Wednesday, giving up three home runs, including a grand slam. Byrd won 15 games last season, in large part because of his propensity to work ahead, but he's often been behind in the count this year.
Right-hander Bartolo Colon, sidelined by a right oblique injury, is expected to resume throwing in the next couple of days. ... The Red Sox are 33-34 all-time at Progressive Field. ... Center fielder Coco Crisp is 5-for-11 (.455) lifetime against Byrd.
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Official game notes
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Wednesday: Red Sox (Clay Buchholz, 0-1, 3.27) at Yankees (Chien-Ming Wang, 3-0, 1.23), 7:05 p.m. ET
Thursday: Red Sox (Josh Beckett, 1-1, 6.35) at Yankees (Mike Mussina, 1-2, 4.15), 7:05 p.m. ET
Friday: Rangers (Luis Mendoza, 0-1, 1.80) at Red Sox (Daisuke Matsuzaka, 3-0, 2.70), 7:05 p.m. ET