Masterson, who is a sinkerball specialist, was a second-round pick of the Red Sox in the 2006 First-Year Player Draft.
His development has been swift, even if this stint in the Majors is all but certain to only be one start.
With Josh Beckett (stiff neck and flu) and Daisuke Matsuzaka (flu) scratched the past two days, the Red Sox had to scramble for a starter to pitch the rubber match of this three-game series against the Angels.
Enter Masterson, who will work with catcher Kevin Cash. Jason Varitek has also been sidelined with the flu and will probably return to the lineup on Saturday night against the Rays.
Cash worked a little with Masterson during Spring Training.
"[He has a] good sinker, pretty good changeup and his slider, I know he was working on," said Cash. "I'm looking forward to it."
BOS: RHP Justin Masterson (Major League debut)
The highly touted Masterson gets the thrill of making his Major League debut at Fenway Park in the finale of this three-game set against the Angels.
LAA: LHP Joe Saunders (3-0, 2.15 ERA)
A pair of Richie Sexson homers got in the way of an otherwise brilliant effort by Saunders against the Mariners on Friday, as he held them to six hits and no walks in eight innings while striking out two. Saunders has been the club's most effective starter in the early going, and he's now 18-8 in 37 career starts. He's 2-0 against the Red Sox with a 2.41 ERA in three career outings, and he won his only start at Fenway Park, giving up one run in 7 2/3 innings last season.
Dustin Pedroia is 4-for-9 lifetime against Saunders. ... Center fielder Coco Crisp will be back in the lineup for the first time in nine days after having right hamstring woes. ... Shortstop Julio Lugo is hitting .457 during his nine-game hitting streak.
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Official game notes
WRKO 680, SBN 1150 (Español)
Friday: Red Sox (Tim Wakefield, 2-0, 3.96) at Rays (Matt Garza, 0-0, 9.00), 7:10 p.m. ET
Saturday: Red Sox (Clay Buchholz, 1-1, 4.79) at Rays (Edwin Jackson, 2-2, 4.63), 7:10 p.m. ET
Sunday: Red Sox (Josh Beckett, 2-1, 5.12) at Rays (James Shields, 2-1, 3.30), 1:40 p.m. ET