Colon, the 2005 American League Cy Young Award winner who signed a Minor League contract with the Red Sox in February, allowed no runs, one hit and struck out one.
The hard-throwing right-hander totaled 19 pitches in his two-inning appearance, reaching as high as 93 mph on the radar gun, and then tossed 16 more in the bullpen just to get additional work.
"Everything sounded real good," said Red Sox manager Terry Francona.
Colon looked like he would soon gain a spot in Boston's rotation before his injury. In his only start this season on April 3 at Triple-A Pawtucket, he threw five scoreless innings of one-hit ball with five strikeouts. But after the game he noted pain in his right oblique and did not pitch again until Monday.
Francona said Colon will join the Sox in Detroit, possibly on Tuesday, and get looked at by team rehab coordinator Mike Reinold. If all is well, Colon will rejoin Pawtucket this weekend to begin an unspecified number of starts.
In Pawtucket, Colon will look to strengthen his arm and gradually increase his workload.
When asked how many starts Colon could make before possibly joining the Red Sox rotation, Francona said, "It probably depends on how he does. You got to get to a certain point where you can expect to go out and not deplete the bullpen. I don't think there will be any issues."
Scott McNeish is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.