"I rounded first base and I didn't know it was out," Lowrie said. "I looked around and none of the umpires made a signal, so I just kept running."
Getting a start on short notice was no problem for Lowrie, who entered the game on an 0-for-11 skid at the plate.
"That's my role right now," Lowrie said. "I have to be ready to play whenever they need me. It's something I'm new at doing, but it's something I hope to continue to get comfortable at."
Lowrie, who finished just a triple shy of the cycle, got his home run ball back from a fan in the left-field stands, thanks to some quick negotiating. The Red Sox provided a Josh Beckett autographed ball in exchange for the Lowrie homer ball.
"Apparently, [Beckett's] signed ball is worth more than my first home run," Lowrie said with a smile.
That home run was certainly worth a lot to the Red Sox, who bounced right back after a tough loss in the bottom of the ninth on Friday.
The Red Sox supported starter Daisuke Matsuzaka with a season-high four homers. Kevin Youkilis and Mike Lowell went deep, in addition to the back-to-back shots by Crisp and Lowrie.
The Twins managed some hard-hit balls in the early going, but Matsuzaka (6-0) seemed to find his groove as he settled in. He wound up going seven innings and allowed six hits and two runs.
"The obvious difference from my previous few starts was really my feel for the ball," Matsuzaka said through his translator.
Matsuzaka did have one blooper-reel moment when his arm came forward on a third-inning pitch as the ball slipped from his grasp. The baseball wound up rolling slowly toward the plate.
"Nice changeup, huh?" Matsuzaka quipped.
Manager Terry Francona liked what he saw from Matsuzaka as the game wore on.
"Against a really aggressive team, I thought he established early that he was going to throw strikes," Francona said. "He got ahead more often that he didn't. As the game progressed, he got into his delivery."
Francona said that because Matsuzaka hung tough early, it allowed Boston's offense an opportunity to get the team over the hump in the late going.
"We took some good swings," Francona said. "We got the back-to-back [homers] and then we add on. Every run helps."
The Red Sox (24-15) can now look past their recent dome doldrums. Prior to Saturday's game, they had lost eight straight in domes.
More good work from Hideki Okajima in the eighth inning and a solid ninth from Jonathan Papelbon sealed the deal. The box score shows that Papelbon was charged with a hit, but only because of a fluke play. Mike Lamb's two-out popup hit a Metrodome wire, changed course and fell out of the reach of catcher Jason Varitek.
It was Boston's night. In particular, it was Lowrie's night.