The injury occurred in the bottom of the third inning. With Brian Roberts on first after a single, Baltimore's Freddie Bynum hit a soft pop to short right field. Drew charged the sinking fly, slid on his backside to try to make the catch and rolled his left glove hand awkwardly beneath him. The ball fell behind him for a single.
"It's one of those plays where you can't protect yourself," said Drew. "The ball hit the web of my glove and took my wrist [back]. I felt it as soon as I jammed it there."
Red Sox trainer Paul Lesnard and bench coach Brad Mills, who is managing the team following the passing of manager Terry Francona's mother-in-law on Monday night, met with Drew in right field. Drew attempted to flex the injured wrist a few times, then walked slowly back to the Boston dugout.
Drew, who reached on an error by Orioles first baseman Kevin Millar in the first and flew to right in the third, was replaced by Jacoby Ellsbury. Drew is hitting .296 with three home runs and 17 RBIs in 33 games.
While playing for the Los Angeles Dodgers in 2005, Drew sustained a broken left wrist when hit by Arizona's Brad Halsey on July 3 and was sidelined for the rest of the season.
Drew wasn't the only Red Sox outfielder not to finish Tuesday's game. Center fielder Coco Crisp succumbed to nausea and severe headaches in the sixth inning, meaning Ellsbury moved to center field and first baseman Kevin Youkilis made his first career appearance in right field.
Mills wasn't sure of the status of Drew, who is day-to-day after X-rays showed no break.
"We're going to have to see what it's like tomorrow," Mills said.
Pete Kerzel is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.