Colon threw a brilliant one-hit gem for Triple-A Pawtucket on Thursday afternoon, as he led the Red Sox to a 2-0 win over the host Buffalo Bisons in the first game of a twin bill between the two clubs.
Ironically, Colon almost duplicated one of the best outings of his career, as he holds the distinction of the being the only man to throw a no-hitter in the 21-year history of Buffalo's Dunn Tire Park when the Bisons, then with the American Association, defeated New Orleans, 4-0, on June 20, 1997.
Colon spent parts of three seasons (1996, 1997 and 2000) with Buffalo while with the Cleveland Indians organization.
On the mend from a strained right oblique muscle that put him on the DL on April 4, the 33-year-old Colon threw 64 pitches, 45 for strikes, in six innings.
Working fast, Colon showed excellent command from start to finish, as he worked both sides of the plate well and threw 15 first-strike pitches with his velocity topping out at 95 mph.
Michael Aubrey got Buffalo's lone hit when he laced a single to right field on a 1-0 count in the fourth inning.
Colon threw 49 pitches over three innings in his last start on May 10 against Norfolk.
The owner of a 146-95 record in his 11 Major League seasons, Colon was the 2005 American League Cy Young Award winner while with the Los Angeles Angels.
Signed as a free agent by the Boston Red Sox on February 25, Colon is trying to return to the Majors, but rotator cuff surgery and nagging elbow problems have limited him to just 29 Major League appearances over the past two seasons.
Colon faced the minimum number of batters and recorded five 1-2-3 innings to improve to 2-0 with Pawtucket.
Dave Ricci is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.