Ramirez started on Friday night and batted three times before coming out in the middle of the seventh with soreness where his hamstring meets the knee. He went 1-for-3 and drove in Boston's only run in a 3-1 loss.
"We played him and ended up taking him out halfway through," said Francona. "It doesn't make a lot of sense to [have him start Sunday]. Give him another day and hopefully he feels better [Monday]."
While he didn't start Saturday, Ramirez pinch-hit in the top of the 10th for Jonathan Papelbon and struck out on three pitches.
"As much as we want him in the lineup, playing half a game doesn't really help us," said Francona. "Just keep checking him out."
Mike Petraglia is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.