While Colon had to go to the disabled list with a back injury, Ramirez merely experienced a tweak in the right hamstring that has bothered him for roughly a month. After exiting in the seventh inning on Tuesday, Ramirez was out of the lineup for Wednesday's series finale against the Phillies.
The Red Sox are off on Thursday and with the designated hitter back in effect when the Sox return to Fenway, Ramirez should be back in the lineup on Friday night against the Cardinals.
"We've got a day game today, day off [Thursday]. We'll try to use some common sense," said Red Sox manager Terry Francona.
Along those same lines, first baseman Kevin Youkilis was out of the lineup for the third straight day with back stiffness.
Youkilis should be back in there on Friday.
"Yeah, I think so," Francona said. "I just think, and again, today, as much as you like having Youk play, you play one and maybe sacrifice three or four, it just doesn't make sense. I think he's making progress. He's sore. We've all had it. You get a back [problem] and it hurts. It will go away."
Without two of their most productive hitters in the lineup, the Sox had Mike Lowell hit cleanup and Sean Casey bat fifth.
Coco Crisp made the start in center field and batted seventh, with Jacoby Ellsbury leading off in left.
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.