After belting homers in three consecutive starts, Crisp left Wednesday's game following his first at-bat with discomfort in his left hand.
Following the game -- a 7-4 win over the Phillies -- the Red Sox seemed relatively certain that the injury is nothing serious.
"He strained, when he swung, like right here [at the top of the hand]," said Red Sox manager Terry Francona. "He iced it. He said he feels OK."
Brandon Moss pinch-hit for Crisp in the third inning and promptly lined a two-run single to center.
Moss remained in the game and went to left field, with Jacoby Ellsbury moving from left to center.
Already, the Red Sox had started the day without Manny Ramirez (sore right hamstring) and Kevin Youkilis (back stiffness).
David Ortiz is on the disabled list with a torn tendon sheath in his left wrist.
Through it all, the Red Sox continue to win. With a 46-29 record, Boston leads the American League East.
Ramirez and Youkilis are both expected back in the lineup on Friday, and Crisp could also be available by then.
"I'm fine," Crisp said.
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.