The Red Sox slugger left Friday's game with left heel soreness in the seventh inning when his spot in the batting order came up. Darnell McDonald replaced him as Boston's designated hitter.
Ortiz was involved in a car accident on his way to Fenway Park earlier in the afternoon, but he was unharmed. He legged out an infield single in the fifth inning, barely beating the throw from Cleveland shortstop Asdrubal Cabrera. Ortiz stayed in the game and reached second base after Adrian Gonzalez walked.
But Ortiz did not return to the game after the fifth. He finished the night 1-for-3 with a walk and a run scored.
"David got that infield hit, and I haven't gotten the complete word, it seemed like when he [hit] the bag, he might have bruised his heel," said manager Bobby Valentine. "That's what was reported to me: Bruised heel, couldn't go. So that's how I think he did it."
McDonald struck out swinging in his first at-bat replacing Ortiz, who has played in all 32 games this season.
Ortiz left the clubhouse before it was opened up to the media and was unavailable for comment.
Austin Laymance is an associate for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.