Besieged by injuries that have kept him from playing for the Red Sox since 2010, Kalish opened a Minor League rehab assignment for Class A Salem on Saturday.
The left-handed hitter started at designated hitter in his debut and was expected to play five innings.
"Take it one little step at a time," said manager Bobby Valentine. "It's great to have him back in uniform and on the field. So, you know, we like him to have success, obviously, but the first step is to play pain free, be healthy and then start putting up some numbers."
Kalish was an everyday player for the Red Sox the final two months of the 2010 season. He went back to the Minors for the start of '11, following Boston's signing of Carl Crawford. Kalish had a nasty collision while playing at Pawtucket last April that led to a variety of injuries.