After making a diving stop to rob Danny Worth of a hit to end the fifth inning, Pedroia came to the dugout and was looked at by the training staff.
It sounds as if Pedroia might have jammed his thumb before the dive, and perhaps that play aggravated it further.
"I was just wondering what happened, because I was going to wear him out," said shortstop Mike Aviles. "In all honesty, I was like, 'You just dove and you came out of the game?' I thought he came out of the game because of the dive. In all honesty, I guess his thumb was jammed pretty good. He got a couple of innings off and I'm pretty sure he's going to be in there tomorrow. There's not that many people that can stop him from getting back in that lineup."
However, manager Bobby Valentine indicated that he doesn't expect to have Pedroia for Tuesday's game, when the Red Sox face Tigers ace Justin Verlander.
"Right now, I don't think he'll play tomorrow," Valentine said.
When Boston took the field for the sixth, Nick Punto replaced Pedroia at second base.
Pedroia certainly finished his work day with a flourish.
"He plays a little up the middle against righties, which is pretty normal," Aviles said. "And for where he had to go to stop that ball and to make a good throw, and he was dealing with that jammed thumb before that, I think that was pretty impressive."
Pedroia went 1-for-3 on Monday and is hitting .295 on the season with five homers and 21 RBIs. The invaluable Pedroia has started all 48 games the Red Sox have played this season.