The night game, to be played at 7:35 p.m., will be the makeup game of Saturday's rainout. Fans who had tickets for Saturday's game must use them for Game 2 on Sunday.
The Red Sox will retire Johnny Pesky's No. 6 before Game 1.
Daisuke Matsuzaka, scheduled to pitch on Saturday, will take the ball in Game 1 for the Red Sox. Veteran knuckleballer Tim Wakefield will start the nightcap.
The Yankees will counter with Mike Mussina, who has a chance to record his first 20-win season, in the opener. Sidney Ponson will pitch opposite Wakefield.
"We'll probably go a little shorter than we would have -- I don't know that we were going to go terribly long with either of them anyway," said Red Sox manager Terry Francona. "And again, not knowing what will happen with the weather, if we get interrupted, we'll make adjustments."
Francona will try to get everybody but Mike Lowell, who is dealing with a painful right hip injury, into one of the games.
Right fielder J.D. Drew, who has played one game since Aug. 17 because of back woes, is penciled in to start Game 1. Coco Crisp and Alex Cora, who have been out of the lineup with nagging injuries the past couple of days, will likely start Game 2.
"It's a long day tomorrow -- it's been a long day today and yesterday," Francona said. "No, it really doesn't [affect our preparation]. We're going to play everybody tomorrow. We actually have -- not set lineups -- but we have posted [tentative] Game 1, Game 2 [lineups], if everything goes according to plan, which it never does."
And after the doubleheader, the Red Sox will congregate at Fenway Park on Monday and then fly to Anaheim for the American League Division Series, which opens on Wednesday.