However, in a positive development, Matsuzaka wiggled out of that jam and even recorded two outs in the sixth before being replaced by Mark Prior.
Matsuzaka went 5 2/3 innings, allowing five hits and five runs, four of which were earned. He walked two and struck out five, throwing 97 pitches.
The righty has been out of action since reinjuring his right trap muscle during a start in Oakland on July 2.
This was Matsuzaka's fourth start of his current rehab assignment. He spent time in the Minors earlier this season, recovering from Tommy John surgery.
The Red Sox can keep Matsuzaka in the Minors until Aug. 29 if they choose. That is when the clock runs out on his 30-day rehab.