"Hamstrings are funny, but I'm staying positive that hopefully maybe one or two games [missed] and we'll go from there," Drew said.
Drew belted a two-run triple to center in the second. Two innings later, he clocked a double to center but pulled up lame at second base.
"Coming around first it really tightened up on me," said Drew. "It hit lower than I [thought it would]," said Drew. "The wind was kind of playing tricks on us, blowing in, coming out, blowing in. I thought I'd hit it halfway up the wall and it hit lower. I came around first and kind of had to hit a second gear to get to second. That's when I felt the tightness come on."
After a brief meeting with manager John Farrell and assistant trainer Masai Takashi at second base, Drew exited.
He was replaced by Brandon Snyder. When the Red Sox went out for defense in the fifth, Snyder went to third base while Jose Iglesias moved to short to replace Drew.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.