Lowrie will soon get on a plane and fly to Durham, N.C., where he will start his rehab assignment for Triple-A Pawtucket on Sunday.
The Red Sox have a loose estimate of a couple of weeks at Triple-A for the shortstop before he is activated.
The way things stand, Lowrie could return shortly before the All-Star break.
"It is like he's starting Spring Training over again and tack on a [left wrist] surgery with it," Red Sox manager Terry Francona said. "Now, we can certainly shape it just for him. In Spring Training, you're trying to work for 60 guys. We have one. We'll probably start out [with him] playing four or five innings.
"There's going to probably have to be a day in between somewhere, not only for his wrist, but for his body. For his arm, everything. I don't know that a couple of weeks is [a bad estimate]. If he's ready, we'll call him up. If he's not, we'll let him play [in Triple-A]. We kind of told him that even though he's a younger kid, he's a very intelligent kid. He's the only one that knows how that wrist feels. We don't want to rush him. We'll do what's right. We don't want to slow him down either. If he's ready to play, he'll play."
In the meantime, Nick Green continues to get the majority of starts at shortstop for the Red Sox. Julio Lugo, who has had limited range since returning from right knee surgery, has started just two games since June 5.
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.