"The good thing is, the group of guys that we have down there in the bullpen all can take this pretty well and understand this is going to happen, but it's not going to happen very often, and move on," Papelbon said.
Justin Masterson, who gave up five runs on five hits in two-plus innings, echoed Papelbon, saying they just have to shake it off.
BOS: RHP Josh Beckett (9-3, 3.48 ERA)
The ace will close out this nine-game road trip with the goal of continuing his recent dominance. Beckett has been nothing short of electric of late. In his past seven starts, he is 5-1 with a 1.24 ERA. In five of his past seven starts, Beckett did not allow an earned run. This is his last start before All-Star selections, and he is looking like a strong candidate to make the team, perhaps even as the starter. He is holding opponents to a .239 average. In eight road starts, he is 5-3 with a 4.03 ERA.
BAL: RHP Brad Bergesen (5-2, 3.76 ERA)
Bergesen continued to shine in his last outing, throwing six innings and giving up just one earned run while striking out five. It was his fifth win of the season and the fourth straight decision he has won. The Orioles have provided him plenty of cushion, scoring 11 runs in his most recent win.
Papelbon's blown save was just his second of the season and the first in his career against the Orioles. ... Boston starters have an impressive 0.90 ERA in 30 innings pitched in their past five games. ... A victory on Wednesday would give the Red Sox a seventh straight series victory.
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Friday: Red Sox (Tim Wakefield, 10-3, 4.18) vs. Mariners (Felix Hernandez, 8-3, 2.54), 7:10 p.m. ET
Saturday: Red Sox (Brad Penny, 6-3, 4.79) vs. Mariners (Garrett Olson, 3-2, 4.81), 1:05 p.m. ET