Buchholz will throw three innings and up to 45 to 50 pitches, the first of either two or three rehab starts before rejoining the Red Sox.
"I thought yesterday's bullpen [session] was the best the ball got out of his hand in any one of the work sessions he's had to date," said manager John Farrell. "If he comes back and pitches as he was, it'd be a great pick up."
Before the right bursa sac strain that has kept him out of action since June 9, Buchholz was 9-0 with a 1.71 ERA in 12 starts.
If Triple-A Pawtucket or one of Boston's other affiliates makes it to the postseason, Buchholz would probably get three starts in the Minors. If not, he will make that third start for Boston -- probably limited to four or five innings.
"If we're limited by options then after this second start, there's always the possibility to bring him back here and have the multi-inning guy right on top of him and continue the progression," said Farrell.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.