Manager John Farrell said it will be an ongoing issue for Ellsbury, who hasn't shown any signs of slowing down over the past three months.
"We're hopeful and expect him to play tomorrow, but I don't think it's going to be gone overnight," Farrell said.
Farrell said the day off Tuesday was to try to "get ahead" of the soreness that's developed in the thumb/palm region of Ellsbury's left hand, the top hand that feels the brunt of the contact on an inside pitch for a left-handed hitter. With Farrell's theory, Ellsbury could need routine days off going forward.
"Everyday players at this time of the year are going to be dealing with certain things," Farrell said. "His happens to be in his left hand."
Jason Mastrodonato is a reporter for MLB.com. Follow him on Twitter @jmastrodonato. This story was not subject to the approval of Major League Baseball or its clubs.