"He's likely to be in the lineup tomorrow in center field, leading off," said manager John Farrell.
Ellsbury will probably be removed after three at-bats.
"Looking forward to getting on the field. It should be fun," said Ellsbury.
With Ellsbury's return looming, Dustin Pedroia moved out of the leadoff spot, where he had been hitting of late, and was restored to the No. 3 spot in the batting order.
Shane Victorino led off Tuesday's game.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.