Sizemore was surprised to even be asked about the incident moments after the game.
"I'm fine," Sizemore offered.
"When he lost his footing and he went down, you recognize that he's going to pivot and torque on the leg. But he came out of it fine," said Red Sox manager John Farrell. "It was good to see him get three at-bats and continue to build [on what he's done so far]."
Sure, he will try to pick his spots more than when he was a young superstar. But Sizemore knows that if his body can't withstand normal aggression, there's no sense in even playing.
"I'm not going to think about it," said Sizemore. "Obviously, I'm going to try and be smart. But I'm still going to play aggressive and try not to change the way I play or think about it while I'm out there."
This was Sizemore's second game in three days, and first against a Major League opponent. He went 1-for-3 against the Twins, lacing a single through the hole at second base and into right field in his final at-bat.
The Red Sox will give Sizemore the next two days off before he returns on Tuesday. Later in the week, he might get a three or four-day break.
"Just to gradually ramp up the overall workload," said Farrell.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.