Ortiz hit another solo homer in the game and ended up going 3-for-5 in the 9-4 victory over the Twins.
Ortiz trails Ted Williams (521) and Carl Yastrzemski (452), two first-ballot Hall of Famers.
Big Papi roped two home runs on Tuesday as part of a 4-for-5, four-RBI performance.
Ortiz came out of the gate swinging on Wednesday, crushing a double to the gap in right-center in his first at-bat and ripping a solo homer in the top of the third. In his eight games prior to Wednesday, Ortiz had a .452 average.
Not only is Ortiz belting the baseball, but he is exuding some swagger.
"It speaks to the way he feels in the box right now," said manager John Farrell. "Even the first pitch he saw, he fouls a fastball straight back. It was interesting listening to his comments before his first at-bat unfolded as he was watching Dustin Pedroia's at-bat unfold. He's in a pretty good place, obviously. As the weather has warmed, David has warmed, and that exudes confidence regardless of what pitch he's addressing inside an at-bat."
Everyone knows that when Ortiz is hot, he is capable of carrying the offense.
"What can I tell you? I've got to stick with the plan. We face the best of the best coming out of everybody and in my case I just have to patient," said Ortiz. "I told you, the weather get hot, Papi gets hot."
Speaking of Ortiz, he gained a hit before getting to the ballpark on Wednesday as his bloop against Yu Darvish in the seventh inning on Friday night -- initially ruled an error on Alex Rios -- was reversed.
"I think it was a hit in the moment," said Farrell. "Upon further review, obviously, they change it. I think in the end, the right call has been had."
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. Teddy Cahill is a reporter for MLB.com. Follow him on Twitter at @tedcahill. This story was not subject to the approval of Major League Baseball or its clubs.