Center fielder and left-handed hitter Grady Sizemore was back in the leadoff spot against Toronto right-hander Drew Hutchison. Sizemore has been there for 10 games this season, but not since April 23. He entered Wednesday hitting .103, going 4-for-39, with a .146 on-base percentage and .154 slugging percentage at the top of the order. Against right-handed starters, he was batting .212/.284/.313.
Second baseman Dustin Pedroia, who had been batting leadoff, dropped down to the second spot.
"Given our performance against right-handed starters," Farrell said, "we may look to have another left-hander in the top part of the order."
Right fielder Shane Victorino moved from second down to sixth. The former switch-hitter has been hitting strictly from the right side this season.
"Had a chance to talk with Vic yesterday," Farrell said. "Against right-handers, he's, it's not been his strong side when compared to facing left-handed starters. And we talked about moving him down in the order a little bit."
The Sox had five left-handed hitters in the starting lineup against Hutchison.
"Here's the thing: we can't stack the lineup with lefties because Jonny [Gomes, playing left field, batting cleanup] being in the lineup. So, we've gone alternating left-right through out. And that's where we are today."
First baseman Mike Napoli was not in the starting lineup because of flu-like symptoms. Mike Carp played first and batted seventh.
Maureen Mullen is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.