Pedroia fouled a ball off his foot in the bottom of the third, but stayed in the game for five more innings before Kelly Johnson replaced him at second base to start the ninth.
"Obviously, he's sore," said Red Sox manager John Farrell. "We'll check him in the morning to see, or when he reports tomorrow, to see if he's available. He's a little bit sore after tonight."
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.