The Blue Jays started left-hander Dana Eveland.
Kevin Youkilis, who usually bats fourth, was moved to third. With Jason Varitek starting at catcher, Victor Martinez on the bench to start the game. J.D. Drew batted fifth.
"We're catching [Varitek] and we wanted Mikey Lowell to play," manager Terry Francona said. "We're looking for balance in the batting order and J.D. has had good swings against this guy and he's a good baserunner, so we're trying to balance everything as best we can."